On viruses to treat cancer

The deliberate use of viruses as oncolytic (cancer killing) agents has become evident since initial observations tracing back to the early 20th century. This thesis explores strategies to enhance oncolytic virotherapy, focusing on genetically engineered Semliki Forest virus. Here, I explore if and how modified viral therapies can enhance immune responses against tumors, especially when designed for single infection and cytokine delivery. Further, I demonstrate through in vitro and computational models that overcoming tumor resistance and promoting rapid inflammatory signaling are critical for effective T cell activation and complete tumor clearance.